Integrin alpha2beta1 (α2β1) promotes prostate cancer skeletal metastasis
نویسندگان
چکیده
منابع مشابه
Activation of Rap1 promotes prostate cancer metastasis.
Elucidating the mechanisms of prostate cancer (CaP) survival and metastasis are critical to the discovery of novel therapeutic targets. The monomeric G protein Rap1 has been implicated in cancer tumorigenesis. Rap1 signals to pathways involved in cell adhesion, migration, and survival, suggesting Rap1 may promote several processes associated with cancer cell metastasis. Examination of CaP cell ...
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The molecular mechanisms underlying metastatic dissemination are still not completely understood. We have recently shown that β(1) integrin-dependent cell adhesion to fibronectin and signaling is affected by a transmembrane molecule, Trop-2, which is frequently upregulated in human carcinomas. Here, we report that Trop-2 promotes metastatic dissemination of prostate cancer cells in vivo and is ...
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Themolecular mechanisms underlying metastatic dissemination are still not completely understood.We have recently shown that b1 integrin-dependent cell adhesion to fibronectin and signaling is affected by a transmembrane molecule, Trop-2, which is frequently upregulated in human carcinomas. Here, we report that Trop-2 promotesmetastatic dissemination of prostate cancer cells in vivo and is abund...
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Osteosarcoma, the most common primary bone tumor in children and young adolescents, is characterized by local invasion and distant metastasis. But the detailed mechanisms of osteosarcoma metastasis are not well known. In the present study, we found that βig-h3 promotes metastatic potential of human osteosarcoma cells in vitro and in vivo. Furthermore, βig-h3 co-localized with integrin α2β1 in o...
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ژورنال
عنوان ژورنال: Clinical & Experimental Metastasis
سال: 2012
ISSN: 0262-0898,1573-7276
DOI: 10.1007/s10585-012-9561-6